Extraction Trichloro-acetic acid is used for extraction of O antigens The H locus contains four exons that span more than 8 kb of genomic DNA
FUT1 encodes a fucosyltransferase that catalyzes the final step in the synthesis of the H antigen The Hh blood group contains one antigen, the H antigen, which is found on virtually all RBCs and is the building block for the production of the antigens within the ABO blood group

Difference between O Antigen and H Antigen

The resulting antigens are oligosaccharide chains, which are attached to lipids and proteins that are anchored in the RBC membrane.

Hydrogen Bonding
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Difference between O Antigen and H Antigen
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Polar Covalent: This type of bond occurs when there is unequal sharing between the two atoms of the electrons in the bond
The individual's RBCs appeared to lack all of the ABO blood group antigens plus an additional antigen that was previously unknown Antibody formation Rapid and Early Rapid and Sustained 4
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Named for the city in which it was first discovered, the "Bombay phenotype" describes individuals whose RBCs lack the H antigen
Difference between O Antigen and H Antigen
The classical Bombay phenotype is caused by a Tyr316Ter mutation in the coding region of FUT1
The Hh blood group
If a person has blood group O, the H antigen remains unmodified
Because fluorine is the most electronegative element, the electrons tend to "hang out" more toward the fluorine atom when fluorine is covalently bonded to other atoms Some of the differences between O Antigen and H Antigen are as follows : S
As a result, these individuals produce anti-H, anti-A, and anti-B and can therefore be transfused only with RBCs that also lacks the H, A, and B antigens i The mutation introduces a stop codon, resulting in a truncated enzyme that lacks 50 amino acids at the C-terminal end, rendering the enzyme inactive

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Likewise, a number of mutations have been reported to underlie the para-Bombay phenotype.

Hydrogen Bonding
Two regions of the genome encode two enzymes with very similar substrate specificities—the H locus FUT1 and the Se locus FUT2
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Nonpolar Covalent: This type of bond occurs when there is equal sharing between the two atoms of the electrons in the bond
The Hh blood group
In 1952, a paper about the "new blood group character related to the ABO blood group" was published